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“The exact role of OPNc in PDA remains to be defined, but it could provide a unique potential target to control pancreatic cancer aggressiveness, ...
NY Does a 2-week improvement in median overall survival justify the use of erlotinib in patients with advanced pancreatic cancer? (J Clin Oncol. 2007;25:1960). Should cetuximab plus chemotherapy be “regarded as a new standard first-line treatment” in ...
NY Dr Fleming and colleagues studied 285 consecutive patients who underwent surgery between 1999-2006 to treat pancreatic adenocarcinoma. Their retrospective analysis was based on prospectively collected data obtained from the institutional database and ...
NY Partially due to these conflicting results with 5-FU–based chemotherapy, trialists have investigated gemcitabine for use in patients with pancreas adenocarcinoma. A randomized trial of gemcitabine versus 5-FU for advanced pancreatic cancer demonstrated ...
NY 14,16,17 This was a phase III study in which 368 pancreatic cancer patients were stratified by resection, tumor, and nodal status following complete resection (R0 or R1) and subsequently randomized to receive six cycles of adjuvant gemcitabine (1000 ...
Fluorouracil vs gemcitabine chemotherapy before and after fl uorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial. JAMA. 2008;299:1019-1026. 5. Kalser MH, Ellenberg SS. Pancreatic cancer. ...